Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. [electronic resource]
- Molecular and cellular biology Jul 2005
- 6090-102 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
0270-7306
10.1128/MCB.25.14.6090-6102.2005 doi
Active Transport, Cell Nucleus Animals Apoptosis Cell Adhesion Cell Adhesion Molecules--antagonists & inhibitors Cell Movement Cell Nucleus--metabolism Epidermal Cells Epidermal Growth Factor--pharmacology Epidermis--growth & development Gene Deletion Gene Targeting Integrin alpha6beta4--genetics Integrin beta4--genetics JNK Mitogen-Activated Protein Kinases--metabolism Keratinocytes--drug effects Mice Mice, Mutant Strains NF-kappa B--metabolism Protein Structure, Tertiary Signal Transduction Wound Healing--genetics Kalinin