DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells. [electronic resource]
- Cancer research Jun 2005
- 5337-43 p. digital
Publication Type: Journal Article
0008-5472
10.1158/0008-5472.CAN-05-0003 doi
Breast Neoplasms--drug therapy Cell Cycle Proteins--biosynthesis Cell Line, Tumor Cross-Linking Reagents--pharmacology Cyclin-Dependent Kinase Inhibitor p21 DNA Damage DNA Replication--drug effects DNA, Neoplasm--drug effects DNA, Single-Stranded--drug effects DNA-Binding Proteins--metabolism Flavonoids--pharmacology Histones--metabolism Humans Nuclear Proteins--biosynthesis Phosphorylation--drug effects Proto-Oncogene Proteins--biosynthesis Proto-Oncogene Proteins c-mdm2 Replication Protein A S Phase--drug effects Tumor Suppressor Protein p53--metabolism