Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. [electronic resource]
- The international journal of biochemistry & cell biology Jul 2005
- 1407-20 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1357-2725
10.1016/j.biocel.2005.01.010 doi
Cell Cycle Proteins--biosynthesis Cell Proliferation--drug effects Cells, Cultured Cellular Senescence--drug effects Comet Assay Cyclin-Dependent Kinase Inhibitor p21 DNA Damage--genetics DNA Repair--genetics Diploidy Electrophoretic Mobility Shift Assay Fibroblasts--drug effects Humans Hydrogen Peroxide--pharmacology Intracellular Signaling Peptides and Proteins--metabolism Oxidative Stress Telomere--drug effects Time Factors Tumor Suppressor Protein p53--biosynthesis beta-Galactosidase--metabolism GADD45 Proteins