TY  - GEN
AU  - Ruderman,Eric M
AU  - Pope,Richard M
TI  - The evolving clinical profile of abatacept (CTLA4-Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis
SN  - 1478-6362
PY  - 2005///1209
KW  - Abatacept
KW  - Animals
KW  - Antigen Presentation
KW  - Antigens, CD
KW  - Antigens, Differentiation
KW  - genetics
KW  - Antirheumatic Agents
KW  - pharmacology
KW  - Arthritis, Experimental
KW  - drug therapy
KW  - Arthritis, Rheumatoid
KW  - Autoimmune Diseases
KW  - B7-1 Antigen
KW  - immunology
KW  - B7-2 Antigen
KW  - CD28 Antigens
KW  - CTLA-4 Antigen
KW  - Clinical Trials, Phase II as Topic
KW  - Clinical Trials, Phase III as Topic
KW  - Double-Blind Method
KW  - Drug Evaluation, Preclinical
KW  - Female
KW  - Humans
KW  - Immunoconjugates
KW  - Immunoglobulin Fc Fragments
KW  - Lymphocyte Activation
KW  - drug effects
KW  - Male
KW  - Mice
KW  - Middle Aged
KW  - Multicenter Studies as Topic
KW  - Pilot Projects
KW  - Protein Structure, Tertiary
KW  - Receptors, Antigen, T-Cell
KW  - Recombinant Fusion Proteins
KW  - therapeutic use
KW  - Treatment Outcome
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review
UR  - https://doi.org/10.1186/ar1688
ER  -