TY  - GEN
AU  - Raje,Noopur
AU  - Kumar,Shaji
AU  - Hideshima,Teru
AU  - Roccaro,Aldo
AU  - Ishitsuka,Kenji
AU  - Yasui,Hiroshi
AU  - Shiraishi,Norihiko
AU  - Chauhan,Dharminder
AU  - Munshi,Nikhil C
AU  - Green,Simon R
AU  - Anderson,Kenneth C
TI  - Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma
SN  - 0006-4971
PY  - 2005///0921
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - pharmacology
KW  - Apoptosis
KW  - Cell Adhesion
KW  - Coculture Techniques
KW  - Cyclin-Dependent Kinases
KW  - antagonists & inhibitors
KW  - DNA-Binding Proteins
KW  - metabolism
KW  - Down-Regulation
KW  - drug effects
KW  - Drug Synergism
KW  - Humans
KW  - Interleukin-6
KW  - genetics
KW  - Multiple Myeloma
KW  - drug therapy
KW  - Myeloid Cell Leukemia Sequence 1 Protein
KW  - Neoplasm Proteins
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - Purines
KW  - Roscovitine
KW  - STAT3 Transcription Factor
KW  - Stromal Cells
KW  - cytology
KW  - Trans-Activators
KW  - Transcription, Genetic
KW  - Tumor Cells, Cultured
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1182/blood-2005-01-0320
ER  -