Thomas, James L <br/><br/>
Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2.  [electronic resource] 

 -  The Journal of biological chemistry  Jun 2005 
 - 21321-8 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M501269200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>3-Hydroxysteroid Dehydrogenases--chemistry<br/>Allosteric Site<br/>Amino Acid Sequence<br/>Androstenols--chemistry<br/>Animals<br/>Arginine--chemistry<br/>Baculoviridae--metabolism<br/>Blotting, Western<br/>Catalysis<br/>Catalytic Domain<br/>Cell Line<br/>DNA Primers--chemistry<br/>Dihydrotestosterone--analogs & derivatives<br/>Dose-Response Relationship, Drug<br/>Electrophoresis, Polyacrylamide Gel<br/>Glutamine--chemistry<br/>Histidine--chemistry<br/>Humans<br/>Insecta<br/>Kinetics<br/>Models, Chemical<br/>Models, Molecular<br/>Molecular Sequence Data<br/>Mutagenesis, Site-Directed<br/>Mutation<br/>NAD--chemistry<br/>Protein Binding<br/>Protein Conformation<br/>Sequence Homology, Amino Acid<br/>Structure-Activity Relationship<br/>Substrate Specificity<br/>Tissue Distribution