TY  - GEN
AU  - Nakaya,Yoshifumi
AU  - Yamane,Takuya
AU  - Shiraishi,Hirohisa
AU  - Wang,Hua-Qin
AU  - Matsubara,Etsuro
AU  - Sato,Toru
AU  - Dolios,Georgia
AU  - Wang,Rong
AU  - De Strooper,Bart
AU  - Shoji,Mikio
AU  - Komano,Hiroto
AU  - Yanagisawa,Katsuhiko
AU  - Ihara,Yasuo
AU  - Fraser,Paul
AU  - St George-Hyslop,Peter
AU  - Nishimura,Masaki
TI  - Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides
SN  - 0021-9258
PY  - 2005///0712
KW  - Allosteric Site
KW  - Amyloid beta-Peptides
KW  - chemistry
KW  - Amyloid beta-Protein Precursor
KW  - Animals
KW  - Binding Sites
KW  - Blotting, Western
KW  - Cell Line
KW  - Cell Membrane
KW  - metabolism
KW  - Centrifugation, Density Gradient
KW  - DNA, Complementary
KW  - Dose-Response Relationship, Drug
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Fibroblasts
KW  - Glycerol
KW  - pharmacology
KW  - Humans
KW  - Immunoblotting
KW  - Immunohistochemistry
KW  - Immunoprecipitation
KW  - Mass Spectrometry
KW  - Membrane Proteins
KW  - genetics
KW  - Mice
KW  - Mutagenesis
KW  - Mutation
KW  - Mutation, Missense
KW  - Presenilin-1
KW  - Protein Isoforms
KW  - Protein Structure, Tertiary
KW  - Proteins
KW  - Receptors, Notch
KW  - Retroviridae
KW  - Subcellular Fractions
KW  - Sulindac
KW  - analogs & derivatives
KW  - Transfection
KW  - Up-Regulation
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1074/jbc.M501130200
ER  -