Nakaya, Yoshifumi <br/><br/>
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.  [electronic resource] 

 -  The Journal of biological chemistry  May 2005 
 - 19070-7 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M501130200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Site<br/>Amyloid beta-Peptides--chemistry<br/>Amyloid beta-Protein Precursor--chemistry<br/>Animals<br/>Binding Sites<br/>Blotting, Western<br/>Cell Line<br/>Cell Membrane--metabolism<br/>Centrifugation, Density Gradient<br/>DNA, Complementary--metabolism<br/>Dose-Response Relationship, Drug<br/>Enzyme-Linked Immunosorbent Assay<br/>Fibroblasts--metabolism<br/>Glycerol--pharmacology<br/>Humans<br/>Immunoblotting<br/>Immunohistochemistry<br/>Immunoprecipitation<br/>Mass Spectrometry<br/>Membrane Proteins--genetics<br/>Mice<br/>Mutagenesis<br/>Mutation<br/>Mutation, Missense<br/>Presenilin-1<br/>Protein Isoforms<br/>Protein Structure, Tertiary<br/>Proteins--chemistry<br/>Receptors, Notch<br/>Retroviridae--genetics<br/>Subcellular Fractions--metabolism<br/>Sulindac--analogs & derivatives<br/>Transfection<br/>Up-Regulation