TY - GEN AU - Vogt,Andreas AU - Tamewitz,Aletheia AU - Skoko,John AU - Sikorski,Rachel P AU - Giuliano,Kenneth A AU - Lazo,John S TI - The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1 SN - 0021-9258 PY - 2005///0712 KW - Alkaloids KW - chemistry KW - Benzophenanthridines KW - Catalytic Domain KW - Cell Cycle Proteins KW - antagonists & inhibitors KW - Cell Line, Tumor KW - DNA Damage KW - Dose-Response Relationship, Drug KW - Dual Specificity Phosphatase 1 KW - Dual Specificity Phosphatase 6 KW - Electrophoresis, Gel, Two-Dimensional KW - Enzyme Inhibitors KW - pharmacology KW - Extracellular Signal-Regulated MAP Kinases KW - metabolism KW - Gene Library KW - HeLa Cells KW - Humans KW - Immediate-Early Proteins KW - Inhibitory Concentration 50 KW - Isoquinolines KW - JNK Mitogen-Activated Protein Kinases KW - MAP Kinase Kinase 4 KW - Microscopy, Fluorescence KW - Mitogen-Activated Protein Kinase Kinases KW - Models, Chemical KW - Models, Statistical KW - Neoplasms KW - drug therapy KW - Phosphoprotein Phosphatases KW - Phosphorylation KW - Plant Extracts KW - Protein Phosphatase 1 KW - Protein Tyrosine Phosphatase, Non-Receptor Type 1 KW - Protein Tyrosine Phosphatases KW - Time Factors KW - Transfection KW - cdc25 Phosphatases N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1074/jbc.M501467200 ER -