The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor of mitogen-activated protein kinase phosphatase-1. [electronic resource]
- The Journal of biological chemistry May 2005
- 19078-86 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M501467200 doi
Alkaloids--chemistry Benzophenanthridines Catalytic Domain Cell Cycle Proteins--antagonists & inhibitors Cell Line, Tumor DNA Damage Dose-Response Relationship, Drug Dual Specificity Phosphatase 1 Dual Specificity Phosphatase 6 Electrophoresis, Gel, Two-Dimensional Enzyme Inhibitors--pharmacology Extracellular Signal-Regulated MAP Kinases--metabolism Gene Library HeLa Cells Humans Immediate-Early Proteins--antagonists & inhibitors Inhibitory Concentration 50 Isoquinolines JNK Mitogen-Activated Protein Kinases--metabolism MAP Kinase Kinase 4 Microscopy, Fluorescence Mitogen-Activated Protein Kinase Kinases--metabolism Models, Chemical Models, Statistical Neoplasms--drug therapy Phosphoprotein Phosphatases--antagonists & inhibitors Phosphorylation Plant Extracts--pharmacology Protein Phosphatase 1 Protein Tyrosine Phosphatase, Non-Receptor Type 1 Protein Tyrosine Phosphatases--antagonists & inhibitors Time Factors Transfection cdc25 Phosphatases--metabolism