Cyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8. [electronic resource]
- The Journal of biological chemistry May 2005
- 19105-14 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M502060200 doi
Androstadienes--pharmacology Animals Anthracenes--pharmacology Apoptosis Blotting, Northern Blotting, Western Bromodeoxyuridine--pharmacology CHO Cells Cell Adhesion Cell Cycle Proteins--metabolism Cell Line, Tumor Cell Proliferation Cricetinae Cyclin-Dependent Kinase Inhibitor p21 Cycloheximide--pharmacology DNA--metabolism Galectins--metabolism Green Fluorescent Proteins--metabolism Humans JNK Mitogen-Activated Protein Kinases--metabolism Ligands MAP Kinase Kinase 4 Mitogen-Activated Protein Kinase Kinases--metabolism Phosphatidylinositol 3-Kinases--metabolism Poly(ADP-ribose) Polymerases--metabolism Protein Kinase Inhibitors--metabolism Protein Synthesis Inhibitors--pharmacology RNA, Messenger--metabolism Reverse Transcriptase Polymerase Chain Reaction Thymidine--pharmacology Time Factors Up-Regulation Wortmannin