TY - GEN AU - Borra,Margie T AU - Smith,Brian C AU - Denu,John M TI - Mechanism of human SIRT1 activation by resveratrol SN - 0021-9258 PY - 2005///0621 KW - Antioxidants KW - pharmacology KW - Binding Sites KW - Binding, Competitive KW - Cell Cycle KW - Chromatography, High Pressure Liquid KW - Coloring Agents KW - Coumarins KW - chemistry KW - Crystallography, X-Ray KW - Gene Silencing KW - Histidine KW - Histone Deacetylases KW - metabolism KW - Humans KW - Immunoprecipitation KW - Kinetics KW - Models, Chemical KW - Models, Molecular KW - Peptides KW - Protein Binding KW - Protein Conformation KW - Resveratrol KW - Rhodamines KW - Sirtuin 1 KW - Sirtuin 2 KW - Sirtuins KW - Stilbenes KW - Substrate Specificity KW - Time Factors KW - Tumor Suppressor Protein p53 N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1074/jbc.M501250200 ER -