Warshamana-Greene, G Sakuntala

The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Feb 2005 - 1563-71 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

1078-0432

10.1158/1078-0432.CCR-04-1544 doi


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Carboplatin--pharmacology
Carcinoma, Small Cell--drug therapy
Cell Division--drug effects
Cell Line, Tumor
Cell Survival--drug effects
Dose-Response Relationship, Drug
Drug Synergism
Enzyme-Linked Immunosorbent Assay
Etoposide--pharmacology
Gene Expression Regulation, Neoplastic--drug effects
Humans
In Situ Nick-End Labeling
Insulin-Like Growth Factor I--pharmacology
Lung Neoplasms--drug therapy
Protein Kinase Inhibitors--pharmacology
Protein Serine-Threonine Kinases--metabolism
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Pyrimidines--pharmacology
Pyrroles--pharmacology
RNA, Messenger--genetics
Receptor, IGF Type 1--antagonists & inhibitors
Vascular Endothelial Growth Factor A--genetics