The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. [electronic resource]
- Clinical cancer research : an official journal of the American Association for Cancer Research Feb 2005
- 1563-71 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
1078-0432
10.1158/1078-0432.CCR-04-1544 doi
Antineoplastic Agents--pharmacology Apoptosis--drug effects Carboplatin--pharmacology Carcinoma, Small Cell--drug therapy Cell Division--drug effects Cell Line, Tumor Cell Survival--drug effects Dose-Response Relationship, Drug Drug Synergism Enzyme-Linked Immunosorbent Assay Etoposide--pharmacology Gene Expression Regulation, Neoplastic--drug effects Humans In Situ Nick-End Labeling Insulin-Like Growth Factor I--pharmacology Lung Neoplasms--drug therapy Protein Kinase Inhibitors--pharmacology Protein Serine-Threonine Kinases--metabolism Proto-Oncogene Proteins--metabolism Proto-Oncogene Proteins c-akt Pyrimidines--pharmacology Pyrroles--pharmacology RNA, Messenger--genetics Receptor, IGF Type 1--antagonists & inhibitors Vascular Endothelial Growth Factor A--genetics