Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. [electronic resource]
- Journal of immunology (Baltimore, Md. : 1950) Mar 2005
- 3041-50 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0022-1767
10.4049/jimmunol.174.5.3041 doi
Animals Arthus Reaction--immunology Cell Line Complement C5a--physiology GTP-Binding Protein alpha Subunit, Gi2 GTP-Binding Protein alpha Subunits, Gi-Go--metabolism Hot Temperature Immunoglobulin G--pharmacology Inflammation Mediators--metabolism Lung--immunology Macrophage Activation--immunology Macrophages, Alveolar--immunology Membrane Proteins--biosynthesis Mice Mice, Inbred C57BL Mice, Knockout Proto-Oncogene Proteins--metabolism Receptor Cross-Talk--immunology Receptor, Anaphylatoxin C5a Receptors, Complement--biosynthesis Receptors, Fc--metabolism Receptors, IgG--deficiency