TY  - GEN
AU  - Baron,Bruce M
AU  - Cregge,Robert J
AU  - Farr,Robert A
AU  - Friedrich,Dirk
AU  - Gross,Raymond S
AU  - Harrison,Boyd L
AU  - Janowick,David A
AU  - Matthews,Donald
AU  - McCloskey,Timothy C
AU  - Meikrantz,Scott
AU  - Nyce,Philip L
AU  - Vaz,Roy
AU  - Metz,William A
TI  - CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist
SN  - 0022-2623
PY  - 2005///0405
KW  - Animals
KW  - Anticonvulsants
KW  - chemical synthesis
KW  - Binding Sites
KW  - Carboxylic Acids
KW  - Cyclic GMP
KW  - biosynthesis
KW  - Glycine
KW  - metabolism
KW  - In Vitro Techniques
KW  - Indoles
KW  - Male
KW  - Mice
KW  - Mice, Inbred DBA
KW  - Models, Molecular
KW  - Neuroprotective Agents
KW  - Phenylacetates
KW  - Quantitative Structure-Activity Relationship
KW  - Radioligand Assay
KW  - Rats
KW  - Rats, Sprague-Dawley
KW  - Receptors, N-Methyl-D-Aspartate
KW  - antagonists & inhibitors
KW  - Seizures
KW  - etiology
KW  - Stereoisomerism
KW  - Stroke
KW  - drug therapy
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm0491849
ER  -