Baron, Bruce M <br/><br/>
CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.  [electronic resource] 

 -  Journal of medicinal chemistry  Feb 2005 
 - 995-1018 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0022-2623 
<br/><br/><label>Standard No.: </label>10.1021/jm0491849  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Anticonvulsants--chemical synthesis<br/>Binding Sites<br/>Carboxylic Acids--chemical synthesis<br/>Cyclic GMP--biosynthesis<br/>Glycine--metabolism<br/>In Vitro Techniques<br/>Indoles--chemical synthesis<br/>Male<br/>Mice<br/>Mice, Inbred DBA<br/>Models, Molecular<br/>Neuroprotective Agents--chemical synthesis<br/>Phenylacetates--chemical synthesis<br/>Quantitative Structure-Activity Relationship<br/>Radioligand Assay<br/>Rats<br/>Rats, Sprague-Dawley<br/>Receptors, N-Methyl-D-Aspartate--antagonists & inhibitors<br/>Seizures--etiology<br/>Stereoisomerism<br/>Stroke--drug therapy