McFadden, Jill M

Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase. [electronic resource] - Journal of medicinal chemistry Feb 2005 - 946-61 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm049389h doi


Animals
Anti-Obesity Agents--chemical synthesis
Antineoplastic Agents--chemical synthesis
Body Weight--drug effects
Cell Line, Tumor
Drug Screening Assays, Antitumor
Fatty Acid Synthases--antagonists & inhibitors
Humans
Mice
Mice, Inbred BALB C
Models, Molecular
Stereoisomerism
Structure-Activity Relationship
Thiophenes--chemical synthesis