TY - GEN AU - Katiyar,Santosh K AU - Roy,Anshu M AU - Baliga,Manjeshwar S TI - Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation SN - 1535-7163 PY - 2005///0728 KW - Amino Acid Chloromethyl Ketones KW - pharmacology KW - Animals KW - Apoptosis KW - Apoptotic Protease-Activating Factor 1 KW - Caspase 3 KW - Caspase Inhibitors KW - Caspases KW - metabolism KW - Cell Line KW - Cysteine Proteinase Inhibitors KW - Cytochromes c KW - Down-Regulation KW - Fibroblasts KW - drug effects KW - Keratinocytes KW - Mice KW - Phosphorylation KW - Poly(ADP-ribose) Polymerases KW - Proteins KW - Proto-Oncogene Proteins c-bcl-2 KW - Silybin KW - Silymarin KW - Tumor Suppressor Protein p53 KW - genetics KW - bcl-2-Associated X Protein N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S ER -