TY - GEN AU - Maude,Shannon L AU - Enders,Greg H TI - Cdk inhibition in human cells compromises chk1 function and activates a DNA damage response SN - 0008-5472 PY - 2005///0314 KW - Ataxia Telangiectasia Mutated Proteins KW - CDC2 Protein Kinase KW - antagonists & inhibitors KW - CDC2-CDC28 Kinases KW - Cell Cycle Proteins KW - metabolism KW - Cell Line, Tumor KW - Checkpoint Kinase 1 KW - Cyclin-Dependent Kinase 2 KW - Cyclin-Dependent Kinases KW - DNA Damage KW - physiology KW - DNA-Binding Proteins KW - Down-Regulation KW - Enzyme Inhibitors KW - pharmacology KW - HeLa Cells KW - Histones KW - Humans KW - Kinetin KW - Protein Kinases KW - biosynthesis KW - Protein Serine-Threonine Kinases KW - Purines KW - Roscovitine KW - Tumor Suppressor Proteins N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S ER -