TY  - GEN
AU  - Das,Anindita
AU  - Xi,Lei
AU  - Kukreja,Rakesh C
TI  - Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling
SN  - 0021-9258
PY  - 2005///0513
KW  - 3',5'-Cyclic-GMP Phosphodiesterases
KW  - Animals
KW  - Apoptosis
KW  - Benzimidazoles
KW  - pharmacology
KW  - Blotting, Western
KW  - Carbocyanines
KW  - Caspase 3
KW  - Caspases
KW  - metabolism
KW  - Cell Survival
KW  - Cells, Cultured
KW  - Cyclic Nucleotide Phosphodiesterases, Type 5
KW  - DNA Primers
KW  - chemistry
KW  - DNA, Complementary
KW  - Enzyme Activation
KW  - Enzyme Inhibitors
KW  - Immunohistochemistry
KW  - In Situ Nick-End Labeling
KW  - L-Lactate Dehydrogenase
KW  - Male
KW  - Membrane Potentials
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Inbred ICR
KW  - Mice, Knockout
KW  - Mitochondria
KW  - Muscle Cells
KW  - Myocytes, Cardiac
KW  - drug effects
KW  - NG-Nitroarginine Methyl Ester
KW  - Necrosis
KW  - Nitric Oxide
KW  - Nitric Oxide Synthase
KW  - Nitric Oxide Synthase Type II
KW  - Nitric Oxide Synthase Type III
KW  - Oxygen
KW  - Phosphodiesterase Inhibitors
KW  - Phosphoric Diester Hydrolases
KW  - Piperazines
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - Purines
KW  - Reverse Transcriptase Polymerase Chain Reaction
KW  - Signal Transduction
KW  - Sildenafil Citrate
KW  - Sulfones
KW  - Time Factors
KW  - Transcription, Genetic
KW  - Trypan Blue
KW  - bcl-X Protein
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1074/jbc.M404706200
ER  -