Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. [electronic resource]
- The Journal of biological chemistry Apr 2005
- 12944-55 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M404706200 doi
3',5'-Cyclic-GMP Phosphodiesterases Animals Apoptosis Benzimidazoles--pharmacology Blotting, Western Carbocyanines--pharmacology Caspase 3 Caspases--metabolism Cell Survival Cells, Cultured Cyclic Nucleotide Phosphodiesterases, Type 5 DNA Primers--chemistry DNA, Complementary--metabolism Enzyme Activation Enzyme Inhibitors--pharmacology Immunohistochemistry In Situ Nick-End Labeling L-Lactate Dehydrogenase--metabolism Male Membrane Potentials Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Knockout Mitochondria--metabolism Muscle Cells--metabolism Myocytes, Cardiac--drug effects NG-Nitroarginine Methyl Ester--metabolism Necrosis Nitric Oxide--metabolism Nitric Oxide Synthase--metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Oxygen--metabolism Phosphodiesterase Inhibitors--pharmacology Phosphoric Diester Hydrolases--metabolism Piperazines--pharmacology Proto-Oncogene Proteins c-bcl-2--metabolism Purines Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Sildenafil Citrate Sulfones Time Factors Transcription, Genetic Trypan Blue--metabolism bcl-X Protein