Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity. [electronic resource]
- Toxicology and applied pharmacology Feb 2005
- 244-57 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0041-008X
10.1016/j.taap.2004.06.026 doi
9,10-Dimethyl-1,2-benzanthracene--pharmacokinetics Animals Aryl Hydrocarbon Hydroxylases--biosynthesis Benzo(a)pyrene--pharmacokinetics Bone Marrow Cells--drug effects Carcinogens, Environmental--pharmacokinetics Cells, Cultured Cytochrome P-450 CYP1A1--biosynthesis Cytochrome P-450 CYP1B1 DNA Adducts--biosynthesis Enzyme Induction In Situ Hybridization Liver--drug effects Lung--drug effects Male Mice Mice, Inbred C57BL Polycyclic Compounds--pharmacokinetics RNA, Messenger--biosynthesis Receptors, Aryl Hydrocarbon--physiology Tissue Distribution