Synergistic interactions between imatinib mesylate and the novel phosphoinositide-dependent kinase-1 inhibitor OSU-03012 in overcoming imatinib mesylate resistance. [electronic resource]
- Blood May 2005
- 4021-7 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
0006-4971
10.1182/blood-2004-07-2967 doi
3-Phosphoinositide-Dependent Protein Kinases Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Benzamides Cell Line, Tumor Drug Resistance, Neoplasm--drug effects Drug Synergism Enzyme Activation--drug effects Fusion Proteins, bcr-abl--genetics Imatinib Mesylate Mice Mutation--genetics Phosphorylation Piperazines--pharmacology Protein Kinase Inhibitors--pharmacology Protein Serine-Threonine Kinases--antagonists & inhibitors Proto-Oncogene Proteins--antagonists & inhibitors Proto-Oncogene Proteins c-akt Pyrazoles--pharmacology Pyrimidines--pharmacology Signal Transduction--drug effects Sulfonamides--pharmacology