Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha-synuclein/phospholipase C (PLCbeta1) interactions. [electronic resource]
- Brain pathology (Zurich, Switzerland) Oct 2004
- 388-98 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1015-6305
10.1111/j.1750-3639.2004.tb00082.x doi
Aged Aged, 80 and over Cell Fractionation--methods Cell Membrane--drug effects Cerebral Cortex--metabolism Dose-Response Relationship, Drug Excitatory Amino Acid Agonists--pharmacology Female Glutamic Acid--pharmacokinetics Guanosine Triphosphate--pharmacology Humans Immunoblotting--methods Immunohistochemistry--methods Immunoprecipitation--methods Lewy Body Disease--metabolism Male Membrane Proteins--metabolism Microscopy, Confocal--methods Middle Aged Nerve Tissue Proteins--metabolism Postmortem Changes Proline--analogs & derivatives Propionates--pharmacology Protein Binding--drug effects Quisqualic Acid--pharmacology Radioligand Assay--methods Receptors, Glutamate--metabolism Signal Transduction--physiology Synaptosomal-Associated Protein 25 Synucleins Tritium--pharmacokinetics Type C Phospholipases--metabolism alpha-Synuclein