Datta, Bansidhar

Treatment of cells with the angiogenic inhibitor fumagillin results in increased stability of eukaryotic initiation factor 2-associated glycoprotein, p67, and reduced phosphorylation of extracellular signal-regulated kinases. [electronic resource] - Biochemistry Nov 2004 - 14821-31 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0006-2960

10.1021/bi049172p doi


Alanine--genetics
Amino Acid Substitution--genetics
Aminopeptidases--biosynthesis
Angiogenesis Inhibitors--metabolism
Animals
Aspartic Acid--genetics
Cell Line
Cyclohexanes
Enzyme Inhibitors--metabolism
Enzyme Stability--drug effects
Eukaryotic Initiation Factor-2--metabolism
Fatty Acids, Unsaturated--metabolism
Female
Glycoproteins--biosynthesis
Inhibitory Concentration 50
Methionyl Aminopeptidases
Mice
Mice, Inbred BALB C
Mitogen-Activated Protein Kinase 1--antagonists & inhibitors
Mitogen-Activated Protein Kinase 3--antagonists & inhibitors
Myoblasts, Skeletal--drug effects
Peptide Fragments--metabolism
Phosphorylation--drug effects
Protein Binding--drug effects
Sesquiterpenes
Transfection