Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein. [electronic resource]
- Molecular and cellular biology Dec 2004
- 10470-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0270-7306
10.1128/MCB.24.23.10470-10478.2004 doi
Amino Acid Motifs Amino Acid Sequence Animals Blotting, Western Bone Marrow Cells--cytology COS Cells Cell Line Cell Nucleus--metabolism Cell Transformation, Neoplastic CpG Islands Cytoplasm--metabolism DNA--chemistry DNA Methylation DNA-Binding Proteins--genetics Gene Deletion Genes, Reporter Histone-Lysine N-Methyltransferase Humans Luciferases--metabolism Mice Microscopy, Fluorescence Models, Genetic Molecular Sequence Data Mutation Myeloid-Lymphoid Leukemia Protein Plasmids--metabolism Point Mutation Protein Binding Protein Structure, Tertiary Proto-Oncogenes--genetics Sequence Homology, Amino Acid Transcription Factors--genetics Transcriptional Activation Translocation, Genetic