Angiotensin II and epidermal growth factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways. [electronic resource]
- The Journal of biological chemistry Jan 2005
- 1582-93 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M408172200 doi
Angiotensin II--pharmacology Animals Cell Line Cyclooxygenase 2 Dose-Response Relationship, Drug Epidermal Growth Factor--pharmacology Epithelial Cells--drug effects Epoprostenol--biosynthesis Gene Expression Regulation, Enzymologic--drug effects Intestines--cytology Mitogen-Activated Protein Kinases--metabolism Monomeric GTP-Binding Proteins--metabolism Prostaglandin-Endoperoxide Synthases--genetics RNA, Messenger--genetics Rats Receptor, Angiotensin, Type 1--metabolism Signal Transduction--drug effects Time Factors Transcription, Genetic--drug effects cdc42 GTP-Binding Protein--metabolism