Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways. [electronic resource]
- Brain research. Molecular brain research Nov 2004
- 161-9 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0169-328X
10.1016/j.molbrainres.2004.06.042 doi
ADAM Proteins ADAM10 Protein Amyloid Precursor Protein Secretases Amyloid beta-Protein Precursor--metabolism Anthracenes--pharmacology Blotting, Western--methods Cell Hypoxia--physiology Cell Line, Tumor Enzyme Inhibitors--pharmacology Gene Expression Regulation--drug effects Humans JNK Mitogen-Activated Protein Kinases--metabolism MAP Kinase Kinase 4 Membrane Proteins--genetics Metalloendopeptidases--genetics Mitogen-Activated Protein Kinase Kinases--metabolism Neuroblastoma--drug therapy Oxazoles--pharmacology Pyridines--pharmacology Signal Transduction--drug effects Stress, Physiological--metabolism Time Factors p38 Mitogen-Activated Protein Kinases--metabolism