TY - GEN AU - Nelson-Degrave,Velen L AU - Wickenheisser,Jessica K AU - Hendricks,Karen L AU - Asano,Tomoichiro AU - Fujishiro,Midori AU - Legro,Richard S AU - Kimball,Scot R AU - Strauss,Jerome F AU - McAllister,Jan M TI - Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome SN - 0888-8809 PY - 2005///0607 KW - Adenoviridae KW - metabolism KW - Androgens KW - biosynthesis KW - Animals KW - Blotting, Western KW - Cell Line KW - Cells, Cultured KW - Dehydroepiandrosterone KW - Dose-Response Relationship, Drug KW - Enzyme Inhibitors KW - pharmacology KW - Extracellular Signal-Regulated MAP Kinases KW - Female KW - Flavonoids KW - Genes, Dominant KW - Humans KW - Insulin KW - Lac Operon KW - Mitogen-Activated Protein Kinase Kinases KW - Mutation KW - Ovary KW - Phosphorylation KW - Polycystic Ovary Syndrome KW - Promoter Regions, Genetic KW - RNA, Messenger KW - Steroid 17-alpha-Hydroxylase KW - Steroids KW - Theca Cells KW - Time Factors KW - Transfection N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1210/me.2004-0178 ER -