Alterations in mitogen-activated protein kinase kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome. [electronic resource]
- Molecular endocrinology (Baltimore, Md.) Feb 2005
- 379-90 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
0888-8809
10.1210/me.2004-0178 doi
Adenoviridae--metabolism Androgens--biosynthesis Animals Blotting, Western Cell Line Cells, Cultured Dehydroepiandrosterone--metabolism Dose-Response Relationship, Drug Enzyme Inhibitors--pharmacology Extracellular Signal-Regulated MAP Kinases--metabolism Female Flavonoids--pharmacology Genes, Dominant Humans Insulin--metabolism Lac Operon Mitogen-Activated Protein Kinase Kinases--metabolism Mutation Ovary--metabolism Phosphorylation Polycystic Ovary Syndrome--metabolism Promoter Regions, Genetic RNA, Messenger--metabolism Steroid 17-alpha-Hydroxylase--biosynthesis Steroids--metabolism Theca Cells--metabolism Time Factors Transfection