TY  - GEN
AU  - Dai,Yun
AU  - Rahmani,Mohamed
AU  - Pei,Xin-Yan
AU  - Khanna,Payal
AU  - Han,Song Iy
AU  - Mitchell,Clint
AU  - Dent,Paul
AU  - Grant,Steven
TI  - Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK
SN  - 0006-4971
PY  - 2005///0303
KW  - Acute Disease
KW  - Alkyl and Aryl Transferases
KW  - antagonists & inhibitors
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - Apoptosis
KW  - drug effects
KW  - Caspases
KW  - metabolism
KW  - Cell Transformation, Neoplastic
KW  - Checkpoint Kinase 1
KW  - Dose-Response Relationship, Drug
KW  - Drug Synergism
KW  - Enzyme Activation
KW  - Enzyme Inhibitors
KW  - Extracellular Signal-Regulated MAP Kinases
KW  - Farnesyltranstransferase
KW  - HL-60 Cells
KW  - Humans
KW  - JNK Mitogen-Activated Protein Kinases
KW  - Jurkat Cells
KW  - Leukemia, Myeloid
KW  - drug therapy
KW  - MAP Kinase Kinase 4
KW  - MAP Kinase Signaling System
KW  - Membrane Potentials
KW  - Methionine
KW  - analogs & derivatives
KW  - Mitochondria
KW  - Protein Kinase Inhibitors
KW  - Protein Kinases
KW  - Protein Serine-Threonine Kinases
KW  - Proto-Oncogene Proteins
KW  - Proto-Oncogene Proteins c-akt
KW  - Staurosporine
KW  - U937 Cells
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S
UR  - https://doi.org/10.1182/blood-2004-07-2767
ER  -