Dai, Yun <br/><br/>
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.  [electronic resource] 

 -  Blood  Feb 2005 
 - 1706-16 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. 
<br/><br/><label>ISSN: </label>0006-4971 
<br/><br/><label>Standard No.: </label>10.1182/blood-2004-07-2767  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acute Disease<br/>Alkyl and Aryl Transferases--antagonists & inhibitors<br/>Antineoplastic Combined Chemotherapy Protocols<br/>Apoptosis--drug effects<br/>Caspases--metabolism<br/>Cell Transformation, Neoplastic--drug effects<br/>Checkpoint Kinase 1<br/>Dose-Response Relationship, Drug<br/>Drug Synergism<br/>Enzyme Activation--drug effects<br/>Enzyme Inhibitors--metabolism<br/>Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors<br/>Farnesyltranstransferase<br/>HL-60 Cells<br/>Humans<br/>JNK Mitogen-Activated Protein Kinases--metabolism<br/>Jurkat Cells<br/>Leukemia, Myeloid--drug therapy<br/>MAP Kinase Kinase 4--metabolism<br/>MAP Kinase Signaling System--drug effects<br/>Membrane Potentials--drug effects<br/>Methionine--analogs & derivatives<br/>Mitochondria--drug effects<br/>Protein Kinase Inhibitors--metabolism<br/>Protein Kinases--metabolism<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Proto-Oncogene Proteins--antagonists & inhibitors<br/>Proto-Oncogene Proteins c-akt<br/>Staurosporine--analogs & derivatives<br/>U937 Cells