TY - GEN AU - Muoio,Deborah M AU - Newgard,Christopher B TI - Biomedicine. Insulin resistance takes a trip through the ER SN - 1095-9203 PY - 2004///1106 KW - Adipose Tissue KW - metabolism KW - Animals KW - Cells, Cultured KW - DNA-Binding Proteins KW - genetics KW - Endoplasmic Reticulum KW - Endoribonucleases KW - Enzyme Activation KW - Homeostasis KW - Humans KW - Insulin KW - Insulin Receptor Substrate Proteins KW - Insulin Resistance KW - physiology KW - Islets of Langerhans KW - Liver KW - Membrane Proteins KW - Mice KW - Mitogen-Activated Protein Kinase 8 KW - Mitogen-Activated Protein Kinases KW - Muscle, Skeletal KW - Nuclear Proteins KW - Obesity KW - Phosphoproteins KW - Phosphorylation KW - Protein Serine-Threonine Kinases KW - Regulatory Factor X Transcription Factors KW - Signal Transduction KW - Transcription Factors KW - eIF-2 Kinase N1 - Publication Type: Journal Article; Comment UR - https://doi.org/10.1126/science.1104680 ER -