TY  - GEN
AU  - Li,Dongxia
AU  - Hirsilä,Maija
AU  - Koivunen,Peppi
AU  - Brenner,Mitchell C
AU  - Xu,Leon
AU  - Yang,Charles
AU  - Kivirikko,Kari I
AU  - Myllyharju,Johanna
TI  - Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation
SN  - 0021-9258
PY  - 2005///0225
KW  - Alanine
KW  - chemistry
KW  - Amino Acid Motifs
KW  - Animals
KW  - Azetidinecarboxylic Acid
KW  - Baculoviridae
KW  - metabolism
KW  - Cell Line
KW  - Chromatography, Liquid
KW  - Culture Media, Serum-Free
KW  - pharmacology
KW  - Glutamic Acid
KW  - Humans
KW  - Hydroxylation
KW  - Hypoxia-Inducible Factor 1, alpha Subunit
KW  - Insecta
KW  - Ketoglutaric Acids
KW  - Kinetics
KW  - Leucine
KW  - Mass Spectrometry
KW  - Methionine
KW  - Models, Chemical
KW  - Peptides
KW  - Procollagen-Proline Dioxygenase
KW  - Proline
KW  - analogs & derivatives
KW  - Protein Structure, Tertiary
KW  - Substrate Specificity
KW  - Time Factors
KW  - Transcription Factors
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1074/jbc.M410287200
ER  -