Li, Dongxia <br/><br/>
Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation.  [electronic resource] 

 -  The Journal of biological chemistry  Dec 2004 
 - 55051-9 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0021-9258 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M410287200  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alanine--chemistry<br/>Amino Acid Motifs<br/>Animals<br/>Azetidinecarboxylic Acid--chemistry<br/>Baculoviridae--metabolism<br/>Cell Line<br/>Chromatography, Liquid<br/>Culture Media, Serum-Free--pharmacology<br/>Glutamic Acid--chemistry<br/>Humans<br/>Hydroxylation<br/>Hypoxia-Inducible Factor 1, alpha Subunit<br/>Insecta<br/>Ketoglutaric Acids--chemistry<br/>Kinetics<br/>Leucine--chemistry<br/>Mass Spectrometry<br/>Methionine--chemistry<br/>Models, Chemical<br/>Peptides--chemistry<br/>Procollagen-Proline Dioxygenase--chemistry<br/>Proline--analogs & derivatives<br/>Protein Structure, Tertiary<br/>Substrate Specificity<br/>Time Factors<br/>Transcription Factors--chemistry