TY - GEN AU - Kakkis,E AU - McEntee,M AU - Vogler,C AU - Le,S AU - Levy,B AU - Belichenko,P AU - Mobley,W AU - Dickson,P AU - Hanson,S AU - Passage,M TI - Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I SN - 1096-7192 PY - 2005///0321 KW - Animals KW - Brain KW - drug effects KW - Disease Models, Animal KW - Dogs KW - Dose-Response Relationship, Drug KW - Glycosaminoglycans KW - metabolism KW - Humans KW - Iduronidase KW - administration & dosage KW - Immune System KW - Injections, Spinal KW - Lysosomes KW - Meninges KW - Mucopolysaccharidosis I KW - drug therapy KW - Recombinant Proteins KW - Reference Values KW - Tissue Distribution N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.ymgme.2004.07.003 ER -