Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. [electronic resource]
- Arthritis and rheumatism Sep 2004
- 2766-74 p. digital
Publication Type: Journal Article
0004-3591
10.1002/art.20460 doi
Adult Aged Aged, 80 and over Antirheumatic Agents--metabolism Arthritis, Rheumatoid--drug therapy Carrier Proteins--genetics Cross-Sectional Studies Erythrocytes--chemistry Female Humans Hydroxymethyl and Formyl Transferases--genetics Male Membrane Proteins--genetics Membrane Transport Proteins--genetics Methotrexate--analogs & derivatives Middle Aged Multienzyme Complexes--genetics Nucleotide Deaminases--genetics Phosphoribosylaminoimidazolecarboxamide Formyltransferase Polyglutamic Acid--analogs & derivatives Polymorphism, Genetic Reduced Folate Carrier Protein Thymidylate Synthase--genetics Treatment Outcome