Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway. [electronic resource]
- The Journal of biological chemistry Nov 2004
- 48615-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.C400396200 doi
Amino Acid Motifs Amyloid Precursor Protein Secretases Amyloid beta-Protein Precursor--chemistry Aspartic Acid Endopeptidases Benzophenones--pharmacology Binding Sites Biotinylation Blotting, Western Catalysis Cell Line Cell Membrane--metabolism Cell-Free System Cross-Linking Reagents--pharmacology DNA, Complementary--metabolism Endopeptidases--chemistry Endoplasmic Reticulum--metabolism Enzyme Inhibitors--pharmacology Epitopes--chemistry Golgi Apparatus--metabolism Humans Membrane Proteins--chemistry Peptide Hydrolases Protein Conformation Protein Structure, Tertiary Receptors, Notch Transfection trans-Golgi Network--chemistry