Electron spin resonance spectroscopy reveals alpha-phenyl-N-tert-butylnitrone spin-traps free radicals in rat striatum and prevents haloperidol-induced vacuous chewing movements in the rat model of human tardive dyskinesia. [electronic resource]
- Synapse (New York, N.Y.) Dec 2004
- 156-63 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0887-4476
10.1002/syn.20078 doi
Analysis of Variance Animals Antipsychotic Agents--toxicity Apomorphine--pharmacology Behavior, Animal Binding Sites Corpus Striatum--drug effects Cyclic N-Oxides Disease Models, Animal Dopamine Agonists--pharmacology Drug Interactions Dyskinesia, Drug-Induced--complications Electron Spin Resonance Spectroscopy Haloperidol--toxicity Humans Male Mastication--drug effects Motor Activity--drug effects Movement Disorders--etiology Neuroprotective Agents--therapeutic use Nitrogen Oxides--therapeutic use Rats Rats, Sprague-Dawley Reactive Oxygen Species--metabolism Receptors, Dopamine D2--physiology