TY - GEN AU - Steckelbroeck,Stephan AU - Jin,Yi AU - Oyesanmi,Busola AU - Kloosterboer,Helenius J AU - Penning,Trevor M TI - Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid SN - 0026-895X PY - 2005///0324 KW - 20-Hydroxysteroid Dehydrogenases KW - metabolism KW - Alcohol Oxidoreductases KW - Aldehyde Reductase KW - Aldo-Keto Reductases KW - Estrogen Receptor Modulators KW - pharmacology KW - Humans KW - Isoenzymes KW - Ketosteroids KW - pharmacokinetics KW - Kinetics KW - Norpregnenes KW - Osteoporosis KW - prevention & control KW - Recombinant Proteins KW - Substrate Specificity N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1124/mol.104.004515 ER -