Steckelbroeck, Stephan <br/><br/>
Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid.  [electronic resource] 

 -  Molecular pharmacology  Dec 2004 
 - 1702-11 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0026-895X 
<br/><br/><label>Standard No.: </label>10.1124/mol.104.004515  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>20-Hydroxysteroid Dehydrogenases--metabolism<br/>Alcohol Oxidoreductases--metabolism<br/>Aldehyde Reductase<br/>Aldo-Keto Reductases<br/>Estrogen Receptor Modulators--pharmacology<br/>Humans<br/>Isoenzymes--metabolism<br/>Ketosteroids--pharmacokinetics<br/>Kinetics<br/>Norpregnenes--pharmacokinetics<br/>Osteoporosis--prevention & control<br/>Recombinant Proteins--metabolism<br/>Substrate Specificity