CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. [electronic resource]
- Molecular cancer therapeutics Sep 2004
- 1147-57 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
1535-7163
Antimetabolites, Antineoplastic--pharmacology Ataxia Telangiectasia Mutated Proteins Base Pair Mismatch Caffeine--pharmacology Cell Cycle--drug effects Cell Cycle Proteins--genetics Cell Line, Tumor Checkpoint Kinase 1 Checkpoint Kinase 2 Colorectal Neoplasms--metabolism DNA Repair--genetics DNA-Binding Proteins Humans Phosphorylation Protein Kinases--genetics Protein Serine-Threonine Kinases--genetics RNA, Small Interfering--genetics Staurosporine--analogs & derivatives Thioguanine--pharmacology Tumor Suppressor Proteins