Williams, Terence M

Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. [electronic resource] - The Journal of biological chemistry Dec 2004 - 51630-46 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M409214200 doi


Animals
Caveolin 1
Caveolins--genetics
Cell Line, Tumor
Cell Membrane--metabolism
Cell Movement
Cells, Cultured
Collagen--pharmacology
Cyclin D1--biosynthesis
Disease Progression
Drug Combinations
Electrophoresis, Polyacrylamide Gel
Enzyme Activation
Female
Gene Expression Regulation, Neoplastic
Immunoblotting
Inhibitory Concentration 50
Laminin--pharmacology
Lung Neoplasms--secondary
Male
Mammary Neoplasms, Animal--genetics
Mammary Tumor Virus, Mouse--genetics
Matrix Metalloproteinase 2--metabolism
Matrix Metalloproteinase 9--metabolism
Mice
Mice, Transgenic
Microscopy, Fluorescence
Mitogen-Activated Protein Kinase 1--biosynthesis
Mitogen-Activated Protein Kinase 3--biosynthesis
Mutation
Neoplasm Invasiveness
Neoplasm Metastasis--genetics
Peptides--chemistry
Phosphorylation
Proteoglycans--pharmacology
Recombinant Proteins--metabolism
Retinoblastoma Protein--metabolism
Retroviridae--genetics
Time Factors
Up-Regulation