Wrigley, Jonathan D J <br/><br/>
Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.  [electronic resource] 

 -  Journal of neurochemistry  Sep 2004 
 - 1312-20 p.  digital 
<br/><br/> Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0022-3042 
<br/><br/><label>Standard No.: </label>10.1111/j.1471-4159.2004.02596.x  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amyloid Precursor Protein Secretases<br/>Amyloid beta-Peptides<br/>Amyloid beta-Protein Precursor--metabolism<br/>Aspartic Acid--chemistry<br/>Aspartic Acid Endopeptidases--pharmacology<br/>Binding Sites--drug effects<br/>Blotting, Western--methods<br/>Cell Line<br/>Cell Membrane--drug effects<br/>Cell-Free System<br/>Cholic Acids--pharmacology<br/>Chromosomal Proteins, Non-Histone--chemistry<br/>Conserved Sequence--physiology<br/>Culture Media, Conditioned--analysis<br/>Detergents--pharmacology<br/>Embryo, Mammalian<br/>Endopeptidases--chemistry<br/>Enzyme Activation--drug effects<br/>Enzyme Inhibitors--pharmacology<br/>Humans<br/>Kidney<br/>Mutagenesis, Site-Directed--physiology<br/>Peptide Fragments<br/>Protein Binding--physiology<br/>Protein Folding<br/>Protein Structure, Tertiary<br/>Substrate Specificity<br/>Transfection<br/>Tyrosine--chemistry