TY - GEN AU - Tateno,Chise AU - Yoshizane,Yasumi AU - Saito,Naomi AU - Kataoka,Miho AU - Utoh,Rie AU - Yamasaki,Chihiro AU - Tachibana,Asato AU - Soeno,Yoshinori AU - Asahina,Kinji AU - Hino,Hiroshi AU - Asahara,Toshimasa AU - Yokoi,Tsuyoshi AU - Furukawa,Toshinori AU - Yoshizato,Katsutoshi TI - Near completely humanized liver in mice shows human-type metabolic responses to drugs SN - 0002-9440 PY - 2004///0930 KW - Adolescent KW - Adult KW - Albumins KW - metabolism KW - Animals KW - Child KW - Chimera KW - Complement C3-C5 Convertases KW - antagonists & inhibitors KW - Complement C3a KW - Cytochrome P-450 Enzyme System KW - genetics KW - Enzyme Induction KW - drug effects KW - Enzyme Inhibitors KW - pharmacology KW - Hepatocytes KW - cytology KW - Heterozygote KW - Homozygote KW - Humans KW - In Situ Hybridization KW - Liver KW - Liver Failure KW - Male KW - Methylcholanthrene KW - Mice KW - Mice, SCID KW - Mice, Transgenic KW - Middle Aged KW - RNA, Messenger KW - analysis KW - Rifampin KW - Transplantation, Heterologous KW - Urokinase-Type Plasminogen Activator N1 - Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/S0002-9440(10)63352-4 ER -