Muzaffar, Saima

Nitroaspirins and morpholinosydnonimine but not aspirin inhibit the formation of superoxide and the expression of gp91phox induced by endotoxin and cytokines in pig pulmonary artery vascular smooth muscle cells and endothelial cells. [electronic resource] - Circulation Aug 2004 - 1140-7 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1524-4539

10.1161/01.CIR.0000139851.50067.E4 doi


Acetophenones--pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Aspirin--analogs & derivatives
Drug Evaluation, Preclinical
Endothelial Cells--drug effects
Endothelium, Vascular--cytology
Enzyme Induction--drug effects
Epoprostenol--biosynthesis
Glycoproteins--biosynthesis
Guanylate Cyclase--antagonists & inhibitors
Interleukin-1--pharmacology
Lipopolysaccharides--toxicity
Male
Molsidomine--analogs & derivatives
Muscle, Smooth, Vascular--cytology
Myocytes, Smooth Muscle--cytology
NADPH Oxidases--biosynthesis
Nitric Oxide--metabolism
Nitric Oxide Donors--pharmacology
Nitro Compounds--pharmacology
Onium Compounds--pharmacology
Pulmonary Artery--cytology
Respiratory Distress Syndrome--metabolism
Superoxides--metabolism
Sus scrofa
Tumor Necrosis Factor-alpha--pharmacology