Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells. [electronic resource]
- BMC microbiology Aug 2004
- 33 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
1471-2180
10.1186/1471-2180-4-33 doi
Adaptor Proteins, Signal Transducing Antigens, Differentiation--metabolism Bacterial Proteins--immunology Cell Line, Tumor Cells, Cultured Central Nervous System Neoplasms--genetics DNA--metabolism Enzyme Activation--physiology Epithelial Cells--enzymology Flagellin--immunology Glioblastoma--genetics HT29 Cells--chemistry HeLa Cells--chemistry Humans I-kappa B Kinase Inflammation--genetics Intestines--microbiology Kidney--chemistry Lung Neoplasms--genetics Membrane Glycoproteins--physiology Mitogen-Activated Protein Kinase Kinases--metabolism Mitogen-Activated Protein Kinases--metabolism Myeloid Differentiation Factor 88 NF-kappa B--metabolism Protein Binding Protein Serine-Threonine Kinases--metabolism Receptors, Cell Surface--physiology Receptors, Immunologic--metabolism Salmonella--immunology Salmonella Infections--pathology Signal Transduction--physiology Solubility Toll-Like Receptor 5 Toll-Like Receptors