Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington's disease. [electronic resource]
- Naunyn-Schmiedeberg's archives of pharmacology Aug 2004
- 131-9 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0028-1298
10.1007/s00210-004-0959-9 doi
Amines--therapeutic use Animals Anticonvulsants--therapeutic use Aza Compounds--blood Corpus Striatum--metabolism Cyclohexanecarboxylic Acids--therapeutic use Disease Models, Animal Female Gabapentin Hippocampus--metabolism Huntington Disease--drug therapy Injections, Subcutaneous Male Mice Mice, Transgenic Motor Activity--drug effects Neuroprotective Agents--therapeutic use Spiro Compounds--blood Survival Rate gamma-Aminobutyric Acid--therapeutic use