Wenk, Jutta

Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediated NFkappaB activation and interleukin-6 release. [electronic resource] - The Journal of biological chemistry Oct 2004 - 45634-42 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M408893200 doi


Active Transport, Cell Nucleus
Cell Line
Collagenases--genetics
Fibroblasts--metabolism
Gene Expression Regulation, Enzymologic--radiation effects
Glutathione Peroxidase--physiology
Humans
Interleukin-6--biosynthesis
Matrix Metalloproteinase 1--genetics
NF-kappa B--metabolism
Phosphatidylcholines--physiology
Phospholipid Hydroperoxide Glutathione Peroxidase
RNA, Messenger--analysis
Skin--cytology
Ultraviolet Rays