TY - GEN AU - Um,Sung Hee AU - Frigerio,Francesca AU - Watanabe,Mitsuhiro AU - Picard,Frédéric AU - Joaquin,Manel AU - Sticker,Melanie AU - Fumagalli,Stefano AU - Allegrini,Peter R AU - Kozma,Sara C AU - Auwerx,Johan AU - Thomas,George TI - Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity SN - 1476-4687 PY - 2004///0930 KW - Adipocytes KW - metabolism KW - Aging KW - physiology KW - Animals KW - Blood Glucose KW - analysis KW - Dietary Fats KW - pharmacology KW - Enzyme Activation KW - Fasting KW - blood KW - Fatty Acids, Nonesterified KW - Gene Deletion KW - Insulin KW - Insulin Receptor Substrate Proteins KW - Insulin Resistance KW - genetics KW - Lipolysis KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Obesity KW - Oxidation-Reduction KW - Phosphoproteins KW - Phosphorylation KW - RNA, Messenger KW - Receptor, Insulin KW - Ribosomal Protein S6 Kinases, 70-kDa KW - deficiency KW - Signal Transduction KW - drug effects N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1038/nature02866 ER -